AS-99 free base

SKU: orb3218239

Description

AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity, blocking cell proliferation, inducing apoptosis and differentiation, downregulating MLL fusion target genes, and reducing the leukemia burden in vivo.

Key Properties

• CAS Number: 2323623-93-2
• MW: 593.68
• Formula: C₂₇H₃₀F₃N₅O₃S₂
• SMILES: CN1CC(C1)C(=O)NCc1ccc2c(cn(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1)-c1cccc(c1)C(N)=S
• Target: Others,Apoptosis,Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others,Apoptosis,Histone Methyltransferase