Argipressin

SKU: orb1685493

Description

Argipressin (Arg8-vasopressin; CAS 113-79-1) suppresses central corticotropin-releasing hormone (CRH), functioning as a repressor in stress response regulation. This peptide is applied in neuroendocrine research using in vivo and in vitro models. 5A2-SC8 is an APC-dependent protein for cellular studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 113-79-1
• MW: 1084.23
• Formula: C₄₆H₆₅N₁₅O₁₂S₂
• SMILES: C(=O)(N1[C@H](C(N[C@H](C(NCC(N)=O)=O)CCCNC(=N)N)=O)CCC1)[C@H]2NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@@H](N)CSSC2
• Target: Vasopressin Receptor
• Solubility: H2O:80 mg/mL (73.79 mM)

Bioactivity

• Target IC50:
  A7r5 cells (rat):1.31 nM (Kd)|A7r5 cells (rat):5 nM (EC50)
• In Vivo:
  In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.
• In Vitro:
  Argipressin exhibits a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells by binding to vasopressin arginine receptor V1. In addition, it stimulated intracellular calcium release in A7r5 cells with an EC50 of 5 nM. Argipressin induces [Ca2+]i signaling in DRG cell cultures and exhibits immunoreactivity against S-100. The lowest effective concentration of Argipressin for inducing [Ca2+]i responses in DRG-cultured non-neuronal cells is 100 pM.

Storage & Handling

• Storage: keep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AVP, Argipressin, Arg8-vasopressin, Vasopressin, Vasopressin Receptor, VasopressinReceptor, Vasopressin receptor 1, Vasopressin receptor 2

Compound Identifiers

PubChem CID

644077