AR7

SKU: orb1303519

Description

AR7

Research Area

Metabolism Research

Key Properties

• CAS Number: 80306-38-3
• MW: 257.71
• Purity: 99.52%
• Formula: C₁₅H₁₂ClNO
• SMILES: Cc1ccc(cc1)C1=Nc2ccc(Cl)cc2OC1
• Target: Retinoid Receptor
• Solubility: DMSO:12.5 mg/mL (48.5 mM)

Bioactivity

• In Vitro:
  Chaperone-mediated autophagy (CMA) contributes to cellular quality control an the cellular response to stress throug the Selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling throug the retinoic acid receptor alpha (RARα) inhibits CMA. AR7, an RARα antagonist, significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment wit the transcriptional repressor Actinomycin D partially reduce the stimulatory effect of AR7 on CMA, consistent with transcriptional Changes contributing to the upregulation of CMA the antagonistic effect o the retinoid derivatives likely results from a combination of tight binding to RARα and high stability.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

AR7, AR-7, AR 7, acid, CMA, Inhibitor, inhibit, macroautophagy, RAR/RXR, RARα, receptor, Retinoic acid receptors, retinoic, RetinoidReceptor, Retinoid Receptor, Retinoid X receptors

Compound Identifiers

PubChem CID

44250175