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AR antagonist 12

SKU: orb3135692

Description

AR antagonist 12 (compound 20i) is an orally active androgen receptor antagonist, demonstrating IC50 values of 119.3 μM for wt-AR and 98.2 μM for AR-F877L. It induces a dose- and time-dependent reduction in the protein levels of AR, AR-v7, and PSA. AR antagonist 12 exhibits anticancer activity, making it useful in the study of Enzalutamide-resistant prostate cancer.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2902679-42-7
MW484.47
FormulaC24H23F3N6O2
SMILESC([C@](C(NC=1C=C(C(F)(F)F)C(C#N)=NC1)=O)(C)O)N2CC3N(C(C2)CC3)C4=CC=C(C#N)C=C4
TargetAndrogen Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information