Androgen receptor antagonist 12

SKU: orb2802363

Description

Compound EF2 is a potent, orally bioavailable androgen receptor (AR) antagonist (IC50 = 0.30 µM) that suppresses mutant AR transcriptional activity and prostate cancer cell proliferation. It blocks AR nuclear translocation and has demonstrated in vivo efficacy by inhibiting tumor growth in C4-2B xenograft models, supporting its use in prostate cancer research.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6605-17-0
• MW: 283.21
• Formula: C₁₂H₈F₃N₃O₂
• SMILES: O=[N+](C1=CN=C(NC2=CC=CC(C(F)(F)F)=C2)C=C1)[O-]
• Target: OCT,Androgen Receptor,OAT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

3257730