Angoline

SKU: orb1297008

Description

Angoline hydrochloride is a potent and selective small molecule inhibitor of the IL-6/STAT3 signaling pathway (IC50: 11.56 µM). It suppresses STAT3 phosphorylation and downstream gene expression, demonstrating anti-proliferative effects in cancer cell studies, making it a valuable research tool for oncology and immunology.

Research Area

Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 21080-31-9
• MW: 379.41
• Purity: 99.96% (May vary between batches)
• Formula: C₂₂H₂₁NO₅
• SMILES: COC1N(C)c2c(ccc3cc4OCOc4cc23)-c2ccc(OC)c(OC)c12
• Target: STAT,Interleukin,IL Receptor
• Solubility: DMSO:9.06 mg/mL (23.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.27 mM)

Bioactivity

• Target IC50:
  IL-6/STAT3 signaling pathway:11.56 μM (IC50)
• In Vitro:
  Angoline as a potent and selective inhibitor of the STAT3 signaling pathway (IC50=11.56 μM). Angoline inhibited STAT3 phosphorylation and its target gene expression and consequently induced growth inhibition of human cancer cells with constitutively activated STAT3 (IC50=3.14-4.72 μM). This work provided a novel lead for the development of anti-cancer agents targeting the STAT3 signaling pathway.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IL Receptor, Inhibitor, ILReceptor, IL-6, inhibit, 6-Methoxyldihydrochelerythrine, Angoline, anticancer, proliferation, STAT3, STAT, phosphorylation

Compound Identifiers

PubChem CID

189060