Angoline

SKU: orb1218462

Description

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.

Key Properties

• CAS Number: 21080-31-9
• MW: 379.41
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₁NO₅
• SMILES: CN(C1OC)c2c(cc3OCOc3c3)c3ccc2-c(cc2)c1c(OC)c2OC
• Target: IL Receptor
• Solubility: In Vitro: DMSO : 20.83 mg/mL (54.90 mM)

Bioactivity

• In Vitro:
  Western blot analysis. Cell line: HepG2/STAT3 cell line. Concentration: 0, 1, 10, 30 and 100 μM. Incubation time: 2 hours. Result: Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells. Cell Proliferation Assay Cell line: MDA-MB-231, H4 and HepG2 cell lines. Concentration: 0-100 μM. Incubation time: 72 hours. Result: Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC50 values of 3.32, 4.72 and 3.14 μM, respectively.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

6-Methoxyldihydrochelerythrine

Quick Database Links

Gene Symbol

IL Receptor