Amorolfine hydrochloride

SKU: orb1224001

Description

Amorolfine Hydrochloride is an antifungal reagent. It exerts the antifungal activity by selectively blocking two steps in the pathway of ergosterol synthesis, and eventually damaging the structure and function of fungal cell membrane. Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.(In Vitro):Amorolfine hydrochloride acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity.Amorolfine hydrochloride (0-128 mg/l) (2-7 days) shows anti-fungal activity for Dermatophyte fungi, Filamentous fungi, Pathogenic yeasts, Dimorphic fungi, Dematiaceous fungi.Amorolfine hydrochloride shows anti-fungal activity with 90% killing corresponding concentrations of 3, 3, 10 and 100 mg/L for Trichophyton mentagrophytes, C. albicans, Histoplasma capsulatum, Cryptococcus neoformans, respectively.(In Vivo):Amorolfine hydrochloride (0.01%-1%; Intravaginal application; twice daily for 3 days) shows anti-fungal activity in rats with vaginal candidiasis.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 78613-38-4
• MW: 353.97
• Purity: >98% (HPLC)
• Formula: C₂₁H₃₆ClNO
• SMILES: CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2C[C@H](O[C@H](C2)C)C.Cl
• Target: Others
• Solubility: Ethanol: 71 mg/mL (200.58 mM); Water: 9 mg/mL (25.42 mM); DMSO: 28 mg/mL (79.1 mM)

Bioactivity

• In Vivo:
  Amorolfine hydrochloride (0.01%-1%; Intravaginal application; twice daily for 3 days) shows anti-fungal activity in rats with vaginal candidiasis. Animal model: Rats (vaginal candidiasis). Dosage: 0.01%-1%. Administration: Intravaginal application; twice daily for 3 days. Result: Produced a dose dependent log reduction in cell count; a concentration of 1 % cleared the vagina of C. albicans completely.
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• In Vitro:
  Amorolfine hydrochloride acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity. Amorolfine hydrochloride (0-128 mg/l) (2-7 days) shows anti-fungal activity for Dermatophyte fungi, Filamentous fungi, Pathogenic yeasts, Dimorphic fungi, Dematiaceous fungi. Amorolfine hydrochloride shows anti-fungal activity with 90% killing corresponding concentrations of 3, 3, 10 and 100 mg/L for Trichophyton mentagrophytes, C. albicans, Histoplasma capsulatum, Cryptococcus neoformans, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ro 14-4767/002

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