Amiodarone hydrochloride

SKU: orb1225774

Description

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 19774-82-4
• MW: 681.78
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₉I₂NO₃·HCl
• SMILES: O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.[H]Cl
• Target: Adrenergic Receptor
• Solubility: Ethanol: 11 mg/mL (16.13 mM); DMSO: 23 mg/mL (33.73 mM)

Bioactivity

• In Vivo:
  Animal model: Ten-week-old male C57BL/6 mice. Dosage: 30, 90, and 180 mg/kg/day. Administration: Treated orally; for 6 weeks. Result: Mice treated with 90 and 180 mg/kg/day had decreased body and heart weights, although their heart weight-to-body weight ratios were not significantly different from sham. 6-week treatment induced a decrease in plasma triiodothyronine and an increase in reverse triiodothyronine. This effect reached significance for the 90 and 180 but not for the 30 mg/kg/day dose groups.
• In Vitro:
  Cell Proliferation Assay Cell line: HELFs. Concentration: 1, 3 and 6 μg/mL. Incubation time: 24 hours. Result: Increased HELFs proliferation compared with the control group. Western blot analysis. Cell line: HELFs. Concentration: 1, 3 and 6 μg/mL. Incubation time: 24 hours. Result: α-SMA and vimentin were increased significantly in a dose-dependent manner. RT-PCR Cell line: HELFs. Concentration: 1, 3 and 6 μg/mL. Incubation time: 24 hours. Result: Induced an increase of α-SMA and vimentin mRNA expression.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Amiodarone hydrochloride | NSC 85442 | NSC-85442 | NSC85442

Quick Database Links

Gene Symbol

Adrenergic Receptor