Amiodarone hydrochloride

SKU: orb1308455

Description

Amiodarone hydrochloride is a class III antiarrhythmic agent that prolongs cardiac action potential by inhibiting potassium and sodium channels. It is widely used in cardiovascular research for studying arrhythmias and, due to its activation of MAPK pathways in fibroblasts, serves as a tool for establishing pulmonary fibrosis models in vivo.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 19774-82-4
• MW: 681.78
• Purity: 99.86% (May vary between batches)
• Formula: C₂₅H₂₉I₂NO₃·HCl
• SMILES: Cl.c1(c2c(oc1CCCC)cccc2)C(=O)c1cc(c(c(c1)I)OCCN(CC)CC)I
• Target: Potassium Channel,Autophagy,Adrenergic Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.47 mM);DMSO:22.73 mg/mL (33.34 mM)

Bioactivity

• Target IC50:
  K+-ATP channel:19.1 μM
• In Vivo:
  Amiodarone penetrates deeply into the lipid matrix of the membrane and is released very slowly from cardiac tissue during washout.Amiodarone inhibits fast sodium channels as well as slow calcium channels.Amiodarone also has non-competitive antiarrhythmic effects and regulates thyroid function and phospholipid metabolism.44-88 μM Amiodarone inhibits Vmax of guinea pig papillary muscle without affecting normal hematopoietic stem cells.44-88 μM Amiodarone inhibits Vmax of guinea pig papillary muscle without affecting normal hematopoietic stem cells. Amiodarone inhibits Vmax in papillary muscle without affecting the resting membrane potential, and this Vmax inhibition is potentiated in a frequency- or use-dependent manner as is the case with class I antiarrhythmic drugs.50-88 μM Amiodarone inhibits depolarization-induced spontaneous action potentials (aberrant automaticity) in ventricular myocardium and Purkinje fibers.50-88 μM Amiodarone inhibits depolarization induced action potentials (aberrant automaticity) in human ventricular muscle.
• In Vitro:
  Amiodarone (AM) inhibits the intracellular conversion from thyroxine (T4) to triiodothyronine (T3) via 5'-deiodination (5'DI) without affecting the intracellular conversion from T4 to reverse T3 (rT3).1.25-25 mg/kg Amiodarone in the AV node and in anaesthetized dogs resulted in a decrease in sinus rate, a prolongation of the AV node effective and functional occlusion of the AV node, as well as frequency-dependent conduction delays. 50 mg/kg daily for 3-4 weeks Amiodarone in rabbit ventricular myocytes resulted in a significant reduction in iK and ito current densities without affecting ICA and IK1 densities.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

benzofuran, Adrenergic Receptor, AdrenergicReceptor, Amiodar, Amiodar HCl, Amiodarone, Amiodarone HCl, antiarrhythmic, arrhythmias, ATP-sensitive potassium (KATP) channels, Autophagy, Nexterone, Potassium Channel, PotassiumChannel, supraventricular, tail, β-adrenergic receptor, ventricular

Compound Identifiers

PubChem CID

441325