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Ac4GalNAz
Catalog Number: orb1219503
| Catalog Number | orb1219503 |
|---|---|
| Category | Small Molecules |
| Description | Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| Target | Alkyl-Chain |
| Purity | >98% (HPLC) |
| MW | 430.37 |
| CAS Number | 653600-56-7 |
| Formula | C16H22N4O10 |
| Storage | Storage temperature: -20°C. Stability: ≥ 2 years |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Ac4GalNAz [orb532363]
mass identification (ESI-MS)
653600-56-7
Theoretical MW: 430.37 g/mol; Detected MW: 430.13 g/mol
C16H22N4O10
100 mgAc4GalNAz [orb1734944]
mass identification (ESI-MS)
653600-56-7
Theoretical MW: 430.37 g/mol; Detected MW: 430.13 g/mol
C16H22N4O10
5 mgAc4GalNAz [orb1734945]
mass identification (ESI-MS)
653600-56-7
Theoretical MW: 430.37 g/mol; Detected MW: 430.13 g/mol
C16H22N4O10
25 mg
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.Note:
- For Reference Only. Please choose the appropriate dissolution protocol according to your experimental animal and administration method.
- We suggest that in cell experiments, the final concentration of DMSO is not more than 0.1%, in animal experiments, for healthy mice, the final concentration of DMSO is not more than 10%; For nude or frail mice, the final concentration of DMSO is not more than 2%.
