5-hydroxytryptamine

SKU: orb1217957

Description

5-hydroxytryptamine is a natural product from animals.

Key Properties

• CAS Number: 50-67-9
• MW: 176.22
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₂N₂O
• SMILES: NCCc1c[nH]c(cc2)c1cc2O
• Target: Others
• Solubility: In Vitro: DMSO : 100 mg/mL (567.47 mM)

Bioactivity

• In Vivo:
  Serotonin produces robust hypersensitivity compared with saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13-/-mice receiving Serotonin compared with IL-13-/-receiving vehicle following induction of DSS colitis.
• In Vitro:
  Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modulation the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki = 44 μM). Results show that addition of 100 μM of Serotonin decreases the reaction velocity of COMT.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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