Zoledronic acid

SKU: orb1300511

Description

Zoledronic acid is a bisphosphonate used to treat bone disorders including Paget's disease, osteoporosis, and malignancy-related hypercalcemia. It is widely applied in oncology and bone metabolism research, with studies demonstrating its efficacy in inhibiting osteoclast-mediated bone resorption in both in vitro and in vivo models.

Research Area

Cancer Biology, Cardiovascular Research, Cell Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 118072-93-8
• MW: 272.1
• Purity: >98%
• Formula: C₅H₁₀N₂O₇P₂
• SMILES: C(P(=O)(O)O)(P(=O)(O)O)(CN1C=CN=C1)O
• Target: Autophagy,Antibacterial,Apoptosis,Rho
• Solubility: Soluble in Water (up to 2 mg/ml) or in DMSO (10 mg/ml).

Bioactivity

• In Vivo:
  Zoledronic acid (120 mg/kg, subcutaneously) prevented damage formation, prevented cancellous bone loss and loss of bone mineral density, and reduced osteoclast circumference in 5T2 mM mice, also decreasing paraprotein concentration and tumor load, and reducing angiogenesis.
  Read more...
• In Vitro:
  Zoledronic acid (120 mg/kg, subcutaneously) prevented damage formation, prevented cancellous bone loss and loss of bone mineral density, and reduced osteoclast circumference in 5T2 mM mice, also decreasing paraprotein concentration and tumor load, and reducing angiogenesis.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGP 42446; Zoledronate

Compound Identifiers

PubChem CID

68740