Zinc pyrithione

SKU: orb1310550

Description

Zinc pyrithione (OM-1563) is a broad-spectrum antimicrobial agent that functions by inhibiting proton pumps, thereby disrupting membrane transport. It is widely used in research for studying microbial physiology, antifungal mechanisms, and membrane transport processes in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 13463-41-7
• MW: 317.71
• Purity: 99.70% (May vary between batches)
• Formula: C₁₀H₈N₂O₂S₂Zn
• SMILES: [O-]1N2C=CC=CC2=[S][Zn+2]13[O-]N4C=CC=CC4=[S]3
• Target: Antibacterial,Cuproptosis,Antifungal,Proton pump
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (6.3 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:33 mg/mL (103.87 mM)

Bioactivity

• In Vivo:
  As a specific synthetic potentiator, Zinc pyrithione activates homotypic and heterotypic M channels by inducing a resting potential. It is considered a zinc complex. The Pyrithione ligand (formally a monoanion) chelates with Zn2+ through oxygen and iron-sulfur centers. In the crystalline state, Zinc pyrithione exists as a centrosymmetric dimer, with each zinc atom coordinated to two sulfur and three oxygen centers. However, in solution, the dimers dissociate through the cleavage of zinc-oxygen bonds. Although Zinc pyrithione is a dimer, its activity causing cytoplasmic membrane depolarization may originate from the monomer, with an effective concentration for half-maximum effect (K1/2) of approximately 0.3 mM.
• In Vitro:
  In exposed mussel tissues, Zinc pyrithione accumulates rapidly, with the rate of accumulation being proportional to both exposure concentration and time. Despite a 7-day LC50 (lethal concentration for 50% of the population) of 8.27 μM in relatively higher concentrations of Zinc pyrithione, this indicates a potential threat to coastal ecosystems and marine life, necessitating further investigation into its sub-lethal biological effects.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Proton Pump, Proton pump, Protonpump, Zinc pyrithione, Bacterial, Fungal, Inhibitor, inhibit, OM 1563, OM1563, OM-1563

Quick Database Links

Gene Symbol

Antibacterial,Cuproptosis,Antifungal,Proton pump