Copper(II) pyrithione

SKU: orb3210642

Description

Copper (II) pyrithione is an inhibitor of New Delhi metallo-β-lactamase 1 (NDM-1). It functions by transmetalation, substituting its zinc (II) cofactor with copper (II), and exhibits cytotoxic effects on pancreatic cancer cells and osteosarcoma cells. Additionally, Copper (II) pyrithione has antimicrobial properties against gram-positive bacteria and certain gram-negative bacteria. It can enhance the efficacy of β-lactam antibiotics against β-lactam-resistant bacteria synergistically. This compound can be utilized in research related to pancreatic cancer, osteosarcoma, and bacterial infections.

Key Properties

• CAS Number: 14915-37-8
• MW: 315.86
• Formula: C₁₀H₈CuN₂O₂S₂
• SMILES: [O-]1N2C=CC=CC2=[S][Cu+2]13[O-]N4C=CC=CC4=[S]3
• Target: Antibacterial

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Antibacterial