Zinc Protoporphyrin

SKU: orb1308919

Description

Zinc Protoporphyrin IX is a competitive, orally active inhibitor of heme oxygenase-1 (HO-1) used to study oxidative stress and cytoprotection in vitro, as it blocks protective agents like phloroglucinol. Its application extends to cancer research, where its anti-proliferative effects are investigated in cellular models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 15442-64-5
• MW: 626.02
• Purity: 95.43% (May vary between batches)
• Formula: C₃₄H₃₂N₄O₄Zn
• SMILES: CC1=C(CCC(O)=O)C2=N\C\1=C/c1c(C=C)c(C)c3\C=C4/N=C(/C=c5/c(C)c(CCC(O)=O)\c(=C\2)n5[Zn]n13)C(C)=C4C=C
• Target: Apoptosis,ROS,Endogenous Metabolite,Reactive Oxygen Species
• Solubility: DMSO:50 mg/mL (79.87 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  Zinc Protoporphyrin exhibits dose-dependent antitumor effects manifested by the retardation of tumor growth.
• In Vitro:
  Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) increased the proportion of late apoptosis and necrotic cells from 10.9% in the control group to 30.4% after 72 hours . Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells. Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle. Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Zinc Protoporphyrin, Zinc Protoporphyrin 9, Zinc Protoporphyrin9, Zinc Protoporphyrin-9, Reactive Oxygen Species, ReactiveOxygenSpecies, Phloroglucinol, Zn(II)-protoporphyrin IX, ZnPP, screening, deficiency,anti-cancer, Apoptosis, Endogenous Metabolite, EndogenousMetabolite, H2O2, Human Endogenous Metabolite, marker, HO-1, heme, Inhibitor, oxygenase-1, inhibit, iron

Compound Identifiers

PubChem CID

439935