Zerumbone

SKU: orb1301560

Description

Zerumbone, a sesquiterpene isolated from Zingiber zerumbet, exhibits antioxidant and anti-inflammatory properties. Its immunomodulatory and hepatoprotective activities are supported by in vitro and in vivo research, making it a compound of interest for inflammation, immunology, and liver disease studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 471-05-6
• MW: 218.34
• Purity: >98%
• Formula: C₁₅H₂₂O
• SMILES: C\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1
• Target: Cytoskeleton
• Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml).

Bioactivity

• In Vivo:
  Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. LPS-induced expressions of proinflammatory mediators, iNOS and COX-2, were inhibited by zerumbone. In addition, NFκB activation and Akt phosphorylation were inhibited by zerumbone in LPS-induced ALI. Suggested that the protective mechanisms of zerumbone on endotoxin-induced ALI were via inhibition of Akt-NFκB activation.
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• Animal Research:
  Mice were pretreated with zerumbone at various concentrations for 30 min followed by intratracheal administration of LPS for 6 h.Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-cancer, anti-inflammatory, antioxidant, anti-proliferative, Inhibitor, Herpes simplex virus, Monocyclic, Epstein-Barr, HSV, inhibit, zerumbone, sesquiterpene, virus

Compound Identifiers

PubChem CID

5470187