zerumbone

SKU: orb1301560

Description

Zerumbone, a sesquiterpene isolated from Zingiber zerumbet, exhibits antioxidant and anti-inflammatory properties. Its immunomodulatory and hepatoprotective activities are supported by in vitro and in vivo research, making it a compound of interest for inflammation, immunology, and liver disease studies.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 471-05-6
• MW: 218.33
• Purity: 99.56%
• Formula: C₁₅H₂₂O
• SMILES: C\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1
• Target: Antifection,Antibacterial,Antioxidant,HSV,Apoptosis,Caspase
• Solubility: DMSO:237.5 mg/mL (1087.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.16 mM)

Bioactivity

• In Vivo:
  Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. LPS-induced expressions of proinflammatory mediators, iNOS and COX-2, were inhibited by zerumbone. In addition, NFκB activation and Akt phosphorylation were inhibited by zerumbone in LPS-induced ALI. Suggested that the protective mechanisms of zerumbone on endotoxin-induced ALI were via inhibition of Akt-NFκB activation.
• Animal Research:
  Mice were pretreated with zerumbone at various concentrations for 30 min followed by intratracheal administration of LPS for 6 h.Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-cancer, anti-inflammatory, antioxidant, anti-proliferative, Inhibitor, Herpes simplex virus, Monocyclic, Epstein-Barr, HSV, inhibit, zerumbone, sesquiterpene, virus

Compound Identifiers

PubChem CID

5470187