zerumbone

SKU: orb1220725

Description

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities contributing to immunomodulatory and hepatoprotective effects.

Key Properties

• CAS Number: 471-05-6
• MW: 218.33
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₂O
• SMILES: C\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1
• Target: Others
• Solubility: DMSO:44 mg/mL (201.53 mM)

Bioactivity

• In Vivo:
  Animal model: Carrageenan (HY-125474)-induced mice paw edema/Cotton pellet-induced granuloma mice. Dosage: 5 mg/kg, 10 mg/kg, 50 mg/kg, 100 mg/kg. Administration: Intraperitoneal injection (i.p.). Result: Significantly produced dose-dependent inhibition of paw oedema induced by carrageenan in mice with inhibition of 33.3, 66.7, 83.3, and 83.3%, respectively. Produced a significant reduction on the granulomatous tissue formation on implanted cotton pellets with inhibition of 34.8, 60.6 and 70.6%, respectively.
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• In Vitro:
  Cell Proliferation Assay Cell line: HeLa, Coav-3, and MCF-7. Concentration: 20.3 μM for HeLa, 24.3 μM for Coav-3, 27.7 μM for MCF-7 Incubation time: 72 h. Result: Showed IC50 values of 20.30 ± 1.1, 24.30 ± 0.9 and 27.7 ± 1.2 μM for HeLa, Coav-3, and MCF-7.Apoptosis Analysis Cell line: HeLa. Concentration: 20.3 μM Incubation time: 72 h. Result: Significantly stimulated caspase-3.Triggered morphological features that relates to apoptosis in a time-dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Others