ZEN-2759

SKU: orb1739105

Description

ZEN-2759 is a potent and selective small molecule inhibitor targeting the bromodomains of BRD4, including BD1, BD2, and the tandem BD1BD2. It is a valuable chemical probe for BET protein research in oncology and inflammation, with utility in both in vitro biochemical assays and in vivo disease model studies.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1616400-50-0
• MW: 280.32
• Purity: 99.36% (May vary between batches)
• Formula: C₁₇H₁₆N₂O₂
• SMILES: CC=1C(C2=CN(CC3=CC=CC=C3)C(=O)C=C2)=C(C)ON1
• Target: Epigenetic Reader Domain
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.13 mM);DMSO:60 mg/mL (214.04 mM)

Bioactivity

• Target IC50:
  BRD4 BD2:0.08 μM|BRD4 BD1:0.23 μM|BRD4 BD1/2:0.28 μM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD4 (1), BRD4 (2), CHF6366, CHF 6366, EpigeneticReaderDomain, Epigenetic Reader Domain, ZEN2759, ZEN-2759, ZEN 2759

Compound Identifiers

PubChem CID

76683643