Zaltoprofen

SKU: orb1224084

Description

Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.(In Vitro):Zaltoprofen (0.1-10 μM; 15 min) inhibits thromboxane B2 production in human platelets in a dose-dependent manner.Zaltoprofen (0.01-1 μM; 30 min) inhibits prostaglandin E2 production by interleukin-1β-stimulated synovial cells.Zaltoprofen (0.1-1 μM; 5 min) inhibits the bradykinin-induced increase of [Ca2+]i in DRG cells.(In Vivo):Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats.Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner.

Key Properties

• CAS Number: 74711-43-6
• MW: 298.36
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₄O₃S
• SMILES: O=C(O)C(C)C1=CC=C(C(C2)=C1)SC3=CC=CC=C3C2=O
• Target: COX
• Solubility: Ethanol: 31 mg/mL (103.9 mM); DMSO: 60 mg/mL (201.09 mM)

Bioactivity

• In Vivo:
  Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats. Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner. Animal model: Eight-week-old male Wistar rats were injected Bradykinin every 15 min. Dosage: 5, 10, 20 mg/kg. Administration: A single p.o. Result: Inhibited bradykinin-induced nociceptive responses, with an ED50 of 9.7 mg/kg. The duration of analgesic effect was 60-90 min.
• In Vitro:
  Zaltoprofen (0.1-10 μM; 15 min) inhibits thromboxane B2 production in human platelets in a dose-dependent manner. Zaltoprofen (0.01-1 μM; 30 min) inhibits prostaglandin E2 production by interleukin-1β-stimulated synovial cells. Zaltoprofen (0.1-1 μM; 5 min) inhibits the bradykinin-induced increase of [Ca2+]i in DRG cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CN 100 | Soleton

Quick Database Links

Gene Symbol

COX