Z-HA155

SKU: orb1309587

Description

Z-HA155 (CS-963) is a potent and selective autotaxin inhibitor with an IC50 of 5.7 nM. It is a valuable research tool for investigating lysophosphatidic acid (LPA) signaling in oncology, fibrosis, and inflammation research, applicable in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1312201-00-5
• MW: 463.29
• Purity: 99.18% (May vary between batches)
• Formula: C₂₄H₁₉BFNO₅S
• SMILES: OB(O)c1ccc(COc2ccc(\C=C3/SC(=O)N(Cc4ccc(F)cc4)C3=O)cc2)cc1
• Target: PDE
• Solubility: DMSO:8 mg/mL (17.27 mM)

Bioactivity

• Target IC50:
  ATX:5.7 nM
• In Vitro:
  HA155 completely attenuates the thrombin-mediated increase in platelet-derived LPA dose-dependently .HA155 is an ATX inhibitor by binding to the ATX active site .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phosphodiesterase (PDE), Z-HA 155, Z-HA155, Z-HA-155, lysophosphatidic, inhibit, LPA, HA155, HA-155, HA 155, Inhibitor, ATX, ATX (autotaxin), autotaxin, acid, CS963, CS-963, CS 963

Compound Identifiers

PubChem CID

46856189