HA 155

SKU: orb1306102

Description

HA 155 (Autotaxin Inhibitor IV) is a potent and selective boronic acid inhibitor of autotaxin (ATX), exhibiting an IC50 of 5.7 nM through covalent interaction with the catalytic threonine. This tool compound is utilized in vitro and in vivo to investigate the lysophosphatidic acid (LPA) signaling pathway in cancer, fibrosis, and inflammation research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1229652-22-5
• MW: 463.29
• Purity: 99.88% (May vary between batches)
• Formula: C₂₄H₁₉BFNO₅S
• SMILES: C(=C1C(=O)N(CC2=CC=C(F)C=C2)C(=O)S1)C3=CC=C(OCC4=CC=C(B(O)O)C=C4)C=C3
• Target: PDE
• Solubility: DMSO:Slightly soluble

Bioactivity

• Target IC50:
  ATX:5.7 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pain, inhibit, Inflammation, Inhibitor, Fibrotic diseases, HA155, HA-155, HA 155, (E/Z)-HA155, Cancer, ATX (autotaxin), Autotaxin, Autotaxin Inhibitor IV, Angiogenesis, Phosphodiesterase (PDE)

Compound Identifiers

PubChem CID

75234210