YZ129

SKU: orb1941072

Description

YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM; also suppressed the expression of NFAT-regulated genes, such as COX2, MMP7, and MMP9, in U87 GBM cells; directly binds to HSP90 to antagonize its chaperoning effect on calcineurin, a Ca2+-sensitive phosphatase that is required for NFAT nuclear translocation and subsequent gene expression; YZ129 could not only suppress cancer cell growth but also reduce cancer cell movement and migration of of GBM cells in vitro; suppresses the growth of GBM xenografts in vivo.

Key Properties

• CAS Number: 1643120-60-8
• MW: 300.317
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₂N₂O₂
• SMILES: O=C(C1=CC=CC=C1C(NC2=CC=C(C=NC=C3)C3=C2)=C4)C4=O
• Target: HSP
• Solubility: In Vitro: DMSO : 5.6 mg/mL (18.65 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YZ-129 | YZ 129

Quick Database Links

Gene Symbol

HSP