YZ129

SKU: orb1689900

Description

YZ129 is a small molecule HSP90 inhibitor that disrupts the HSP90-calcineurin-NFAT pathway, blocking NFAT nuclear translocation (IC₅₀ = 820 nM). It induces G2/M phase arrest, apoptosis, and inhibits proliferation and migration in glioblastoma cells, making it a candidate for in vitro and in vivo neuro-oncology research.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1643120-60-8
• MW: 300.31
• Formula: C₁₉H₁₂N₂O₂
• SMILES: O=C1C=C(Nc2ccc3cnccc3c2)c2ccccc2C1=O
• Target: Others,Apoptosis,HSP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

137628683