YM-155

SKU: orb1224011

Description

A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM; does not significantly inhibit SV40 promoter activity (>30 uM); suppresses expression of survivin and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nM, without effect on IAP- or Bcl-2-related proteins; induces massive tumor regression in PC-3 tumor mice model (3-10 mg/kg).Blood Cancer Phase 1 Discontinued.

Key Properties

• CAS Number: 781661-94-7
• MW: 443.2939
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₉BrN₄O₃
• SMILES: O=C(C1=C2[N+](CCOC)=C(C)N1CC3=NC=CN=C3)C4=C(C=CC=C4)C2=O.[Br-]
• Target: IAP
• Solubility: DMSO: 10.66 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YM155 | Sepantronium bromide | YM 155

Quick Database Links

Gene Symbol

IAP