YM-155

SKU: orb1306455

Description

Sepantronium bromide (YM155) is a proapoptotic small molecule that suppresses survivin expression, demonstrating antineoplastic activity. It is widely used in cancer research, showing efficacy in both in vitro cell culture studies and in vivo xenograft models across various cancer types.

Research Area

Cell Biology

Key Properties

• CAS Number: 781661-94-7
• MW: 443.30
• Purity: >98%
• Formula: C₂₀H₁₉BrN₄O₃
• SMILES: [Br-].COCCn1c(C)[n+](Cc2cnccn2)c2c1C(=O)c1ccccc1C2=O
• Target: Autophagy,Survivin
• Solubility: Soluble in DMSO (up to 25 mg/ml).

Bioactivity

• Target IC50:
  Survivin:0.54 nM
• In Vivo:
  Subcutaneous injection of 3 and 10 mg/kg YM155 into prostate transplantation tumors showed that YM155 completely inhibited the tumor growth of PC-3 with no decrease in weight and no decrease in blood cell count. Moreover, 5 mg/kg YM155 showed 80% tumor inhibition in PC-3 ectopic graft tumors.The combination of YM155 and γ-radiation showed high antitumor activity against H460 or Calu6 xenografts in nude mice.
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• In Vitro:
  Subcutaneous injection of 3 and 10 mg/kg YM155 into prostate transplantation tumors showed that YM155 completely inhibited the tumor growth of PC-3 with no decrease in weight and no decrease in blood cell count. Moreover, 5 mg/kg YM155 showed 80% tumor inhibition in PC-3 ectopic graft tumors.The combination of YM155 and γ-radiation showed high antitumor activity against H460 or Calu6 xenografts in nude mice.
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• Cell Research:
  Cells are seeded in 96-well plates at a density of 5-40 × 103. YM155 is dissolved in DMSO and added to cells for 48 hours. Then the cell count is determined by sulforhodamine B assay. (Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sepantronium bromide

Compound Identifiers

PubChem CID

11178236