YKL-06-061

SKU: orb1301677

Description

YKL-06-061 is a potent and selective small-molecule inhibitor of salt-inducible kinases (SIKs), demonstrating high selectivity with IC50 values of 6.56 nM (SIK1), 1.77 nM (SIK2), and 20.5 nM (SIK3). This compound is a valuable research tool for investigating SIK signaling pathways in both cellular and animal models of inflammation, fibrosis, and metabolic regulation.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 2172617-15-9
• MW: 527.66
• Purity: 99.99% (May vary between batches)
• Formula: C₃₀H₃₇N₇O₂
• SMILES: COc1cc(ccc1Nc1ncc2CN(C(=O)N(C3CCC3)c2n1)c1c(C)cccc1C)N1CCN(C)CC1
• Target: SIK,AMPK
• Solubility: DMSO:5.28 mg/mL (10.01 mM);H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.9 mM)

Bioactivity

• Target IC50:
  SIK3:20.5 nM|SIK2:1.77 nM|SIK1:6.56 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Salt-inducible Kinase (SIK), YKL 06 061, YKL06061, YKL-06-061, SIK1, SIK3, SIK2

Compound Identifiers

PubChem CID

132992144