YKL 06-061

SKU: orb1225652

Description

YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively; inhibits only one kinase FRK (IC50=1.1 nM), more strongly than SIKs, in a panel of 468 human kinases; dose-dependently increases MITF mRNA expression in human melanoma cells; induces significant pigmentation in Mc1r-deficient mice and normal human skin.

Key Properties

• CAS Number: 2172617-15-9
• MW: 527.673
• Purity: >98% (HPLC)
• Formula: C₃₀H₃₇N₇O₂
• SMILES: O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C
• Target: SIK
• Solubility: DMSO : 62.5 mg/mL 118.45 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  YKL 06-061 yields a dose-dependent increase in MITF mRNA expression.: RT-PC R Cell line: UACC62 human melanoma cells, and UACC257 human melanoma cells. Concentration: 0-4 μM (UACC62); 0-16 μM (UACC257). Incubation time: 3 hours. Result: Yielded a dose-dependent increase in MITF mRNA expression.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YKL06-061

Quick Database Links

Gene Symbol

SIK