YH239-EE

SKU: orb1301033

Description

YH239-EE

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 1364488-67-4
• MW: 504.41
• Purity: 99.61%
• Formula: C₂₅H₂₇Cl₂N₃O₄
• SMILES: CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(N(Cc1ccc(Cl)cc1)C=O)C(=O)NC(C)(C)C
• Target: E1/E2/E3 Enzyme,Apoptosis,MDM-2/p53
• Solubility: DMSO:93 mg/mL (184.37 mM);Ethanol:15 mg/mL (29.74 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
• Cell Research:
  Cell lines are harvested in log-phase growth and seeded following exposure to p53-MDM2 antagonists. Cell number and viability are determined by staining cells with Trypan blue 0.4% and counted with Countess slides.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E3Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E1 activating enzyme, E1 Enzyme, E2 conjugating enzyme, E2 Enzyme, E2Enzyme, E3 ligating enzyme, E3 Enzyme, Apoptosis, MDM-2/p53, Inhibitor, inhibit, p53/MDM2, Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme, YH239 EE, YH239EE, YH-239-EE, YH239-EE

Compound Identifiers

PubChem CID

56943013