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YH239-EE

SKU: orb1226442

Description

YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4; induces apoptosis in AML cells and patient samples, induces p53 and activates the apoptotic caspase 3/7 in MOLM-13 (wt-p53) cells.

Images & Validation

Key Properties

CAS Number1364488-67-4
MW504.4056
Purity>98% (HPLC)
FormulaC25H27Cl2N3O4
SMILESO=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC
TargetMDM2-p53
SolubilityDMSO: ≥ 55 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

YH 239-EE | YH 239 EE

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Protocol Information

YH239-EE (orb1226442)

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Available Sizes

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200 mg
500 mg
5 mg
$ 110.00
10 mg
$ 160.00
25 mg
$ 290.00
50 mg
$ 500.00
100 mg
$ 730.00