YAP-TEAD-IN-2

SKU: orb1944811

Description

YAP-TEAD-IN-2 (compound 6) is a highly potent, nanomolar-range inhibitor of the YAP-TEAD protein-protein interaction, with an IC50 of 2.7 nM. This small molecule is a valuable chemical probe for fundamental research into the Hippo signaling pathway and has been utilized in both in vitro and in vivo cancer models to study oncogenic transcription driven by this PPI.

Research Area

Cancer Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2714432-83-2
• MW: 470.92
• Formula: C₂₅H₂₄ClFN₂O₄
• SMILES: O=C(C1=CC=C(C(F)=C1C2=C3C[C@@](C4=CC=CC=C4)(CN)OC3=CC=C2Cl)OCCOC)N
• Target: YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176418814