Xylocaine

SKU: orb1226415

Description

Lidocaine, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.(In Vitro):Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation.Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10 nM and treatment time 48 hours.Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate.Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly.(In Vivo):Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block.

Key Properties

• CAS Number: 137-58-6
• MW: 234.34
• Purity: >98% (HPLC)
• Formula: C₁₄H₂₂N₂O
• SMILES: O=C(NC1=C(C)C=CC=C1C)CN(CC)CC
• Target: Histamine Receptor
• Solubility: Ethanol: 47 mg/mL (200.56 mM); Water: 9 mg/mL (38.4 mM); DMSO: 47 mg/mL (200.56 mM)

Bioactivity

• In Vivo:
  Lidocaine GMP (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by Lidocaine GMP has slower onset and faster recovery compared with thermal nociception block.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 40030

Quick Database Links

Gene Symbol

Histamine Receptor