Lidocaine

SKU: orb1310583

Description

Lidocaine (Alphacaine) is an amide-type local anesthetic that also demonstrates anti-inflammatory properties in both in vitro and in vivo studies. Its mechanism may involve attenuating ICAM-1 expression, reducing pro-inflammatory cytokines, and limiting neutrophil influx, making it a useful research tool in inflammation and immunology studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 137-58-6
• MW: 234.34
• Purity: >99.99% (May vary between batches)
• Formula: C₁₄H₂₂N₂O
• SMILES: N(C(CN(CC)CC)=O)C1=C(C)C=CC=C1C
• Target: ERK,NF-κB,Histamine Receptor,Sodium Channel,MEK,Apoptosis
• Solubility: DMSO:50 mg/mL (213.37 mM);H2O:21.34 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.53 mM)

Bioactivity

• Target IC50:
  H1 receptor:>32 μM

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alphacaine, Apoptosis, NF-κB, NF-kB, NFkB, NFκB, Nuclear factor-κB, Nuclear factor-kappaB, Mitogen-activated protein kinase kinase, Na channels, Na+ channels, Lignocaine, Lidocaine, inhibit, Histamine Receptor, HistamineReceptor, MEK, MAPKK, MAP2K, Inhibitor, H1 receptor, Extracellular signal regulated kinases, ERK, SodiumChannel, Sodium Channel, Xylocaine

Compound Identifiers

PubChem CID

3676