XMD16-5

SKU: orb1226502

Description

XMD16-5 is a potent Ack1 (TNK2) inhibitor with IC50 of 0.38 uM in ELISA assay; exhibits potent inhibition of growth of the TNK2 mutant expressing cell lines with IC50s of 16 nM and 77 nM for the D163E and R806Q mutations.

Key Properties

• CAS Number: 1345098-78-3
• MW: 416.47566
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₄N₆O₂
• SMILES: OC(CC1)CCN1C(C=C2)=CC=C2NC3=NC=C4C(N(C)C(C=CC=C5)=C5C(N4)=O)=N3
• Target: Ack1 (TNK2)
• Solubility: DMSO: ≥ 29 mg/mL

Bioactivity

• In Vitro:
  XMD16-5 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1, 000 nM). XMD16-5 has IC50s of 16 nM and 77 nM for the D163E and R806Q mutations. The effects of XMD16-5 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD16-5.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

XMD16-5 | XMD-16-5 | XMD 16-5 | XMD165

Quick Database Links

Gene Symbol

Ack1 (TNK2)