XMD-17-51 Trifluoroacetate

SKU: orb1218300

Description

XMD-17-51 Trifluoroacetate is a potent and highly selective NUAK1 inhibitor.

Key Properties

• CAS Number: 2436579-93-8
• MW: 518.49
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₅F₃N₈O₃
• SMILES: O=C1N(C)C2=CN=C(NC3=CN(C4CCNCC4)N=C3)N=C2N(C)C5=CC=CC=C15.FC(C(O)=O)(F)F
• Target: AMPK
• Solubility: DMSO:80 mg/ml (197.78 mM); Ethanol:8 mg/ml (19.78 mM); Water:2 mg/ml (4.94 mM)

Bioactivity

• In Vitro:
  XMD-17-51 TFA is a pyrimido-diazepinone compound that is able to modulate protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1, 2, 3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK, ULK2, PLK, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and can be used in the treatment of various diseases, disorders or conditions.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

XMD-17-51 Trifluoroacetate (1628614-50-5 free base)

Quick Database Links

Gene Symbol

AMPK