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XL413

SKU: orb1695994

Description

XL-413 is an orally available, selective CDC7 kinase inhibitor that disrupts DNA replication initiation, leading to cell cycle arrest and apoptosis. It is used in cancer research to study replication stress and has shown antitumor activity in both cellular and animal models of CDC7-overexpressing cancers.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1169558-38-6
MW289.72
Purity99.94%
FormulaC14H12ClN3O2
SMILESO=C1C2=C(C=3C(O2)=CC=C(Cl)C3)NC(=N1)[C@@H]4CCCN4
TargetCasein Kinase,Cholecystokinin Receptor,CDK,Pim
SolubilityDMSO:2.9 mg/mL (10.01 mM)

Bioactivity

Target IC50
CDC7:3.4 nM|Pim1:42 nM|pMCM:118 nM(EC50)|CK2:215nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cyclin dependent kinase, CDK, Cdc7, CK2, CaseinKinase, Casein Kinase, Inhibitor, inhibit, XL 413, XL413, XL-413, PIM1

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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XL413 (orb1695994)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 160.00
10 mg
$ 210.00
25 mg
$ 340.00
50 mg
$ 540.00
100 mg
$ 740.00
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