XL413 xHCl

SKU: orb1738141

Description

XL413 HCl is a potent and selective, ATP-competitive inhibitor of Cdc7 kinase (IC50: 3.4 nM), with additional activity against PIM1 and CK2. It has been utilized in research to study DNA replication and cell cycle progression in various cancer models, demonstrating utility in both in vitro and in vivo experimental settings.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1169562-71-3
• MW: 326.18
• Purity: 99.67% (May vary between batches)
• Formula: C₁₄H₁₂ClN₃O₂.xHCl
• SMILES: Cl.Clc1ccc2oc3c(nc([nH]c3=O)[C@@H]3CCCN3)c2c1
• Target: Pim,CDK,Casein Kinase
• Solubility: DMSO:3.1 mg/mL;H2O:9 mg/mL

Bioactivity

• Target IC50:
  CDC7:3.4 nM|pMCM:118 nM(EC50)|CK2:215 nM|Pim1:42 nM
• In Vivo:
  XL413 HCl (10, 30, or 100 mg/kg; p.o.; mice) is well tolerated at all doses, with no significant body weight loss. XL413 HCl (100 mg/kg; p.o.; mice) show excellent plasma exposures in mice and possesses good PK properties.
• In Vitro:
  XL413 HCl shows cytotoxic effects on tumors, with IC50 of 22.9 µM in HCC1954 cells and 1.1 µM in Colo-205 cells. BMS-863233 HCl is an effective DDK inhibitor in vitro, with an IC50 of 22.7 nM. XL413 HCl is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS-863233 xHCl, BMS-863233 HCl, Cdc7, CK2, Casein Kinase, CaseinKinase, Pim1, XL413 hydrochloride, XL413 Hydrochloride, XL-413 Hydrochloride, XL 413 Hydrochloride

Compound Identifiers

PubChem CID

135564631