XL177A

SKU: orb1218306

Description

XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.

Key Properties

• CAS Number: 2417089-74-6
• MW: 861.47
• Purity: >98% (HPLC)
• Formula: C₄₈H₅₇ClN₈O₅
• SMILES: O=C(NC1=CC(N=CN2CC3(O)CCN(C([C@H](CC4=CC=CC=C4)CCCNC(C5=CC(N=C(CCCC6)C6=C7Cl)=C7C=C5)=O)=O)CC3)=C(C=C1)C2=O)CCN8CCN(C)CC8
• Target: DUB
• Solubility: In Vitro: DMSO : 25 mg/mL (29.02 mM)

Bioactivity

• In Vitro:
  Western blot analysis. Cell line: MCF7 cells. Concentration: 0.001, 0.01, 0.1, 1, 10 μM Incubation time: 18-24 hours. Result: The p53 and p21 protein levels remained high, but MDM2 protein levels matched DMSO control.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DUB