XL177A

SKU: orb1089362

Description

XL177A is a potent USP7 inhibitor. XL177A irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome. Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells.

Key Properties

• CAS Number: 188719-92-8
• MW: 130.1882
• Purity: >98%
• Formula: C₆H₁₄N₂O
• SMILES: O([H])/N=C(/C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])\N([H])[H]

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

24688409