XE991

SKU: orb1944530

Description

XE991 dihydrochloride is a selective Kv7 (KCNQ) channel blocker that potently inhibits Kv7.1, Kv7.2, and Kv7.2/7.3 heteromers, thereby suppressing the neuronal M-current. It is widely used in vitro and in vivo to investigate the role of these channels in epilepsy, pain, and cognitive disorders.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 122955-42-4
• MW: 376.45
• Purity: 99.51% (May vary between batches)
• Formula: C₂₆H₂₀N₂O
• SMILES: O=C1C=2C=CC=CC2C(C=3C=CC=CC13)(CC=4C=CN=CC4)CC=5C=CN=CC5
• Target: Potassium Channel

Bioactivity

• Target IC50:
  [3H]-acetylcholine:490 nM
• In Vitro:
  XE991 and DMP 543 have EC50 values of 490 nM and 700 nM, respectively, for enhancing [3H] acetylcholine release from rat brain slices.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Kv7.1, Kv7.2, PotassiumChannel, Potassium Channel

Compound Identifiers

PubChem CID

656732