ICA069673

SKU: orb1223093

Description

ICA069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively). ICA-069673 inhibited spontaneous phasic, pharmacologically induced, and nerve-evoked contractions in DSM isolated strips in a concentration-dependent manner. ICA-069673 decreased the global intracellular Ca(2+) concentration in DSM cells, an effect blocked by the L-type Ca(2+) channel inhibitor nifedipine. ICA-069673 hyperpolarized the membrane potential and inhibited spontaneous action potentials of isolated DSM cells, effects that were blocked in the presence of XE991.

Key Properties

• CAS Number: 582323-16-8
• MW: 269.63
• Purity: >98% (HPLC)
• Formula: C₁₁H₆CLF₂NO₃
• SMILES: c1cc(c(cc1C(=O)Nc1cnc(nc1)Cl)F)F
• Target: FAK
• Solubility: DMSO : ≥ 34 mg/mL; 126.10 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ICA-069673 | ICA 069673 | ICA069673

Quick Database Links

Gene Symbol

FAK