WS-6

SKU: orb1226318

Description

A small molecule that can induce proliferation of β cells with EC50 of 0.28 uM; promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation; acts by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription; also stimulates α cell proliferation in human pancreatic islets.

Key Properties

• CAS Number: 1421227-53-3
• MW: 568.59
• Purity: >98% (HPLC)
• Formula: C₂₉H₃₁F₃N₆O₃
• SMILES: O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)CC3=CC=C(OC4=NC=NC(NC(C5CC5)=O)=C4)C=C3
• Target: IκB kinase (IKK)
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

WS6 | WS 6

Quick Database Links

Gene Symbol

IκB kinase (IKK)