WRX606

SKU: orb1910987

Description

WRX606 is a nonrapalog inhibitor. WRX606 formed a ternary complex with FK506-binding protein-12 (FKBP12) and FKBP−rapamycin-binding (FRB) domain of mTOR, resulting in the allosteric inhibition of mTORC1. WRX606 inhibited the phosphorylation of not only the ribosomal protein S6 kinase 1 (S6K1) but also eIF4E-binding protein-1 (4E-BP1). Hence, WRX606 efficiently suppressed tumor growth in mice without promotion of metastasis. These results suggest that WRX606 is a potent lead compound for developing anticancer drugs discovered by in silico and in cell methods.

Key Properties

• CAS Number: 899937-47-4
• MW: 548.974305868149
• Purity: >98%
• Formula: C₂₈H₂₅CLN₄O₆
• SMILES: N1(CC(NC2=CC=CC(Cl)=C2)=O)C2=C(C=CC=C2)C(=O)N(CCCC(NCC2=CC=C3OCOC3=C2)=O)C1=O

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only