WRN inhibitor 20

SKU: orb3181569

Description

WRN inhibitor 20 (Compound 14c) is a WRN degrader demonstrating significant degradation activity in various cells, including HCT-116 (DC50 = 1.7 µM), SW-48 (DC50 = 3.0 µM), and SW-480 (DC50 = 5.9 µM). This compound shows strong antiproliferative effects, promotes apoptosis, inhibits migration, and induces DNA damage in MSI-H cells, making it a valuable tool for cancer research.

Key Properties

• CAS Number: 3095277-20-3
• MW: 727.84
• Formula: C₃₇H₄₄F₃N₅O₅S
• SMILES: O=C(NC1=CC=C(C=C1)C)CNS(=O)(=O)C2=NC(=CC(=N2)C(F)(F)F)C=3C=CC(OCCCCCNC(=O)CC45CC6CC(CC(C6)C4)C5)=CC3
• Target: DNA/RNA Synthesis,Apoptosis

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

DNA/RNA Synthesis,Apoptosis