WRN inhibitor 16

SKU: orb2814140

Description

WRN inhibitor 16 (Example 83) is an orally bioavailable small molecule targeting the Werner syndrome helicase. In preclinical studies using a SW48 colorectal cancer xenograft model, it demonstrated inhibitory activity but did not induce tumor regression. This tool compound is useful for investigating WRN's role in DNA repair and microsatellite unstable cancers.

Research Area

Cell Biology, Epigenetics & Chromatin; Pharmacology & Drug Discovery, Molecular Biology

Key Properties

• MW: 646.65
• Formula: C₃₁H₃₀F₄N₄O₅S
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis