KWR095

SKU: orb2944504

Description

KWR095 is a potent, orally bioavailable WRN inhibitor with an IC50 of 0.032 µM against its ATPase activity. It blocks WRN's helicase function, suppressing cancer cell growth in vitro, and is a valuable tool for studying DNA repair mechanisms and synthetic lethality in MSI-H cancer models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 3057980-16-9
• MW: 710.105
• Formula: C₃₃H₃₁ClF₃N₉O₄
• SMILES: O=C(C1=NC=CC=2C=CNC21)N3CCN(C=4C(=O)N5N=C(N=C5N(C4CC)CC(=O)NC6=CC=C(C=C6Cl)C(F)(F)F)C7=CCOCC7)CC3
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176222182