Wnt agonist 1

SKU: orb1221726

Description

BML-284, also known as AMBMP and Wnt agonist 1, is a potent and selective activator of Wnt signaling. It enhances beta-catenin and increases transcript and protein levels of p-gp.

Key Properties

• CAS Number: 853220-52-7
• MW: 386.83
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈N₄O₃·HCl
• SMILES: Nc1nc(c2cccc(OC)c2)cc(NCc2ccc3OCOc3c2)n1.Cl
• Target: Wnt
• Solubility: DMSO : ≥ 30 mg/mL; 85.62 mM

Bioactivity

• In Vivo:
  BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7: EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos.
• In Vitro:
  BML-284 (10 μM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen (HY-B0115). BML-284 (10 μM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group. Western blot analysis. Cell line: Human gastric cancer cell lines MNK45 and AGS. Concentration: 10 μM. Incubation time: 24 hours. Result: Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMBMP HCl | AMBMP Hydrochloride | Wnt Agonist | BML 284 HCl

Quick Database Links

Gene Symbol

Wnt