Withanolide A

SKU: orb1297175

Description

Withanolide A is a natural steroidal lactone shown to prolong lifespan in a C. elegans model of EGFR-driven cancer. This compound is utilized in aging and oncology research, with applications in both in vivo longevity studies and in vitro investigations of its anti-proliferative mechanisms.

Research Area

Cardiovascular Research, Cell Biology, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 32911-62-9
• MW: 470.60
• Purity: 99.50% (May vary between batches)
• Formula: C₂₈H₃₈O₆
• SMILES: [H][C@@]12CC[C@H]([C@@](C)(O)[C@@]3([H])CC(C)=C(C)C(=O)O3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H]2O[C@@H]2[C@@]2(O)CC=CC(=O)[C@]12C
• Target: Apoptosis,TNF,Gamma-secretase,EGFR,NF-κB
• Solubility: DMSO:55.00 mg/mL (116.87 mM);10% DMSO+90% Corn Oil:1.67 mg/mL (3.55 mM)

Bioactivity

• In Vitro:
  A quantitative structure activity relationship (QSAR) model was developed by a forward stepwise multiple linear regression method to predict the activity of Withanolide Analogs against human breast cancer. The most effective QSAR model for anticancer activity against the SK-Br-3 cell showed the best correlation with activity (r2=0.93 and rCV2 =0.90). Similarly, cross-validation regression coefficient (rCV2=0.85) of the best QSAR model against the MCF7/BUS cells showed a high correlation (r2=0.91). In particular, compounds CID 73621, CID 435144, CID 301751 and CID 3372729 have a marked antiproliferative activity against the MCF7/BUS cells, while 2,3-dihydrowithaferin A-3-beta-O-sulfate, withanolide 5, Withanolide A, withaferin A, CID 10413139, CID 11294368, CID 53477765, CID 135887, CID 301751 and CID 3372729 have a high activity against the Sk-Br-3 cells compared to standard drugs 5-fluorouracil (5-FU) and camptothecin
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, NFkB, NF-kB, NFκB, NF-κB, EGFR, Inhibitor, Withanolide A, TNF-α

Compound Identifiers

PubChem CID

11294368