Withaferin A

SKU: orb1301583

Description

Withaferin A is a steroidal lactone that acts as a novel inhibitor of the NF-κB signaling pathway. It is a promising research compound for studying inflammation and oncology, demonstrating activity in both cellular assays and animal models of disease.

Research Area

Cardiovascular Research, Cell Biology

Key Properties

• CAS Number: 5119-48-2
• MW: 470.60
• Purity: >98%
• Formula: C₂₈H₃₈O₆
• SMILES: C[C@@H]([C@H]1CC[C@H]2[C@@H]3C[C@H]4O[C@]44[C@@H](O)C=CC(=O)[C@]4(C)[C@H]3CC[C@]12C)[C@H]1CC(C)=C(CO)C(=O)O1
• Target: Cytoskeleton
• Solubility: Soluble in DMSO (up to 20 mg/ml)

Bioactivity

• In Vivo:
  WITHAFERIN A Displays Anti-inflammatory Properties in Vivo—Because NFκB is a critical player in the inflammatory signaling pathway and because WITHAFERIN A inhibits NFκB activation.
• In Vitro:
  WITHAFERIN A,potently inhibits NFkappaB activation by preventing the tumor necrosis factor-induced activation of IkappaB kinase beta via a thioalkylation-sensitive redox mechanism.
• Cell Research:
  L929sA cells were co-treated with WITHAFERIN A and DTT for 1 h, and then TNF-induced NFκB activation was examined.
• Animal Research:
  Mice are injected subcutaneously with zymosan in the footpad, and swelling is determined at several time points after the injection. Pretreatment with WITHAFERIN A(intraperitoneal) was performed to evaluate anti-inflammatory effects, whereas DEX (intraperitoneal) was chosen as a positive control. the mean of the differences between the zymosan-treated and untreated footpad for all the three groups. Both DEX.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC-101088

Compound Identifiers

PubChem CID

265237