4-oxo Withaferin A

• Catalog Number: orb1693353
• Category: Small Molecules
• Description: 4-oxo Withaferin A
• CAS Number: 6850-30-2
• Purity: 98%
• MW: 468.59
• SMILES: [H][C@@]12C[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)[C@@]5([H])CC(C)=C(CO)C(=O)O5)[C@@]4(C)CC[C@]3([H])[C@@]3(C)C(=O)C=CC(=O)[C@@]13O2 |c:37,t:17|
• Formula: C₂₈H₃₆O₆
• Biological Activity: 4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and < 1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.